Blar i forfatter "Popp, Ilinca"

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    • External Validation of the Graded Prognostic Assessment in Patients with Brain Metastases from Small Cell Lung Cancer 

      Nieder, Carsten; Popp, Ilinca; Hintz, Mandy; Grosu, Anca Ligia (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-29)
      Background: Recently, graded prognostic assessment (GPA) for small cell lung cancer (SCLC) patients with brain metastases has been developed. This includes age, performance status, number of brain metastases and presence of extracranial metastases. The aim of the present study was to validate this four-tiered prognostic score in a European cohort of patients. Methods: The retrospective validation ...

    • Hippocampus-Avoidance Whole-Brain Radiation Therapy Is Efficient in the Long-Term Preservation of Hippocampal Volume 

      Popp, Ilinca; Rau, Alexander; Kellner, Elias; Reisert, Marco; Fennell, Jamina; Rothe, Thomas; Nieder, Carsten; Urbach, Horst; Egger, Karl; Grosu, Anca L.; Kaller, Christoph P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-19)
      Background and Purpose: With improved life expectancy, preventing neurocognitive decline after cerebral radiotherapy is gaining more importance. Hippocampal damage has been considered the main culprit for cognitive deficits following conventional whole-brain radiation therapy (WBRT). Here, we aimed to determine to which extent hippocampus-avoidance WBRT (HA-WBRT) can prevent hippocampal atrophy ...

    • Hippocampus-avoidance whole-brain radiation therapy with a simultaneous integrated boost for multiple brain metastases 

      Popp, Ilinca; Rau, Stephan; Hintz, Mandy; Schneider, Julius; Bilger, Angelika; Fennell, Jamina Tara; Heiland, Dieter Henrik; Rothe, Thomas; Egger, Karl; Nieder, Carsten; Urbach, Horst; Grosu, Anca-Ligia (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-06)
      <i>Background</i> - The current study was aimed at investigating the feasibility of hippocampus‐avoidance whole‐brain radiation therapy with a simultaneous integrated boost (HA‐WBRT+SIB) for metastases and at assessing tumor control in comparison with conventional whole‐brain radiation therapy (WBRT) in patients with multiple brain metastases.<p> <p><i>Methods</i> - Between August 2012 and December ...

    • Long-term survival results after treatment for oligometastatic brain disease 

      Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-04)
      Aim - The aim of this study was to characterize the survival results of patients with up to four brain metastases after intense local therapy (primary surgery or stereotactic radiotherapy) if extracranial metastases were absent or limited to one site, e.g. the lungs.<p> <p>Background - Oligometastatic disease has repeatedly been reported to convey a favorable prognosis.<p> <p>Material and ...

    • PRO: Do We Still Need Whole-Brain Irradiation for Brain Metastases? 

      Popp, Ilinca; Hartong, Nanna E.; Nieder, Carsten; Grosu, Anca-L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-15)
      (1) Background: In recent decades, the use of whole-brain radiation therapy (WBRT) in the treatment of brain metastases has significantly decreased, with clinicians fearing adverse neurocognitive events and data showing limited efficacy regarding local tumor control and overall survival. The present study thus aimed to reassess the role that WBRT holds in the treatment of brain metastases. (2) ...

    • Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA) 

      Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-13)
      <i>Purpose</i> - The purpose of this study was to validate a new prognostic model (GI-GPA) originally derived from a multi-center database (USA, Canada, Japan).<p><p> <i>Patients and Methods</i> - This retrospective study included 92 German and Norwegian patients treated with individualized approaches, always including brain radiotherapy. Information about age, extracranial spread, number of brain ...